ABSTRACT
Current computer-aided diagnosis system with deep learning method plays an important role in the field of medical imaging. The collaborative diagnosis of diseases by multiple medical institutions has become a popular trend. However, large scale annotations put heavy burdens on medical experts. Furthermore, the centralized learning system has defects in privacy protection and model generalization. To meet these challenges, we propose two federated active learning methods for multicenter collaborative diagnosis of diseases: the Labeling Efficient Federated Active Learning (LEFAL) and the Training Efficient Federated Active Learning (TEFAL). The proposed LEFAL applies a task-agnostic hybrid sampling strategy considering data uncertainty and diversity simultaneously to improve data efficiency. The proposed TEFAL evaluates the client informativeness with a discriminator to improve client efficiency. On the Hyper-Kvasir dataset for gastrointestinal disease diagnosis, with only 65% of labeled data, the LEFAL achieves 95% performance on the segmentation task with whole labeled data. Moreover, on the CC-CCII dataset for COVID-19 diagnosis, with only 50 iterations, the accuracy and F1-score of TEFAL are 0.90 and 0.95, respectively on the classification task. Extensive experimental results demonstrate that the proposed federated active learning methods outperform state-of-the-art methods on segmentation and classification tasks for multicenter collaborative disease diagnosis.